MTC-004 (NCT00000000)— Phase 1 Study of TMV Vaccine Alone or with Toripalimab-tpzi in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC). Metaclipse Therapeutics and MD Anderson Cancer Center.

MYTHIC (NCT04855656) — Open-label Phase 1 dose-escalation trial of lunresertib (RP-6306), a PKMYT1 inhibitor, alone and in combination with camonsertib (RP-3500), an ATR inhibitor, in advanced solid tumors. Repare Therapeutics and UCSF.

NST-628-001 (NCT06326411) — Phase 1, open-label, single-arm, two-part study of oral pan-RAF/MEK molecular glue NST-628 in solid tumors harboring RAS-MAPK pathway alterations. Nested Therapeutics and UCSF.

NX-1607-101 (NCT05107674) — First-in-human Phase 1a/1b, multicenter, open-label study of oral CBL-B inhibitor NX-1607 in adults with advanced malignancies. Nurix Therapeutics and UCSF.

HOXTON (NCT04644770) — Phase 1 study of JNJ-69086420, an Actinium-225-labeled antibody targeting human kallikrein-2 (hK2), for advanced prostate cancer.  Johnson & Johnson.

PALOMA (NCT04606381) — Open-label, multicenter, dose-escalation Phase 1b study assessing safety and pharmacokinetics of subcutaneous amivantamab, a bispecific EGFR/cMet antibody, in advanced solid malignancies.  Johnson & Johnson.

Standard vs. Lower Pressure — Randomized controlled trial comparing standard-pressure (15 mmHg) against two lower-pressure (10 mmHg, 12 mmHg) pneumoperitoneum during conventional laparoscopic gynecologic surgery, including endometriosis excision, myomectomy, and hysterectomy. Enrolled 147 patients to evaluate postoperative pain scores, opioid requirements, and surgeon-rated visualization at each pressure level, informing individualized intraoperative pressure selection based on patient and surgical factors. Cedars-Sinai Medical Center

Biologic and Epidemiologic Markers of Endometriosis (BEME) — Identifies biomarkers of benign gynecologic conditions, with a focus on endometriosis. Cedars-Sinai Medical Center.

Gynecologic Tissue Bank (Study 901) — Institutional biorepository supporting research of gynecologic cancers and diseases. Cedars-Sinai Medical Center.

Peritoneal Entry in Laparoscopic Surgery — Compares blunt-forceps abdominal entry against traditional needle technique for setup time, success rate, and postoperative pain. Cedars-Sinai Medical Center

Disparities and Outcomes in Gynecologic Surgery — Ongoing cohort study examining disparities in access to minimally invasive gynecologic procedures among women of color. Cedars-Sinai Medical Center.